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Table 2 ROC curve of GABA (μmol/L), serotonin (ng/mL), dopamine (ng/L), oxytocin (μLU/mL), and IFI16 (ng/mL) in autistic groups

From: Association of social and cognitive impairment and biomarkers in autism spectrum disorders

   Patients with autism CARS SRS
Parameters Mild to moderate Severe Mild to moderate Severe
GABA (μmol/L) Area under the curve 0.883 0.843 1.000 0.864 0.993
  Best cutoff value 0.170 0.170 0.257 0.170 0.257
  Sensitivity% 90.0% 85.7% 100.0% 91.7% 93.3%
  Specificity% 80.0% 80.0% 100.0% 80.0% 100.0%
Serotonin (ng/mL) Area under the curve 1.000 1.000 0.997 1.000 1.000
  Best cutoff value 59.925 55.225 56.400 51.700 56.400
  Sensitivity% 100.0% 100.0% 96.0% 100.0% 100.0%
  Specificity% 100.0% 100.0% 100.0% 100.0% 100.0%
Dopamine (ng/L) Area under the curve 0.968 0.993 0.959 1.000 0.969
  Best cutoff value 477.771 463.014 490.207 433.682 490.207
  Sensitivity% 92.9% 100.0% 94.1% 100.0% 100.0%
  Specificity% 88.9% 92.6% 85.2% 100.0% 85.2%
Oxytocin (μLU/mL) Area under the curve 0.981 0.973 0.990 0.979 0.989
  Best cutoff value 92.105 92.105 85.555 92.105 109.720
  Sensitivity% 90.0% 85.2% 95.7% 90.0% 100.0%
  Specificity% 100.0% 100.0% 100.0% 100.0% 90.0%
IFI16 (ng/mL) Area under the curve 0.933 0.916 0.973 0.918 0.978
  Best cutoff value 1.750 1.750 2.320 1.860 2.330
  Sensitivity% 100.0% 100.0% 92.0% 90.5% 95.2%
  Specificity% 70.0% 70.0% 90.0% 80.0% 90.0%
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