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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Anti-inflammatory effects of astroglial α7 nicotinic acetylcholine receptors are mediated by inhibition of the NF-κB pathway and activation of the Nrf2 pathway

Fig. 7

α7 nAchR activation reduced inflammatory astrocyte-mediated neuronal apoptosis. a Representative images of caspase activation in neurons treated with astrocyte conditioned media in the presence of LPS (60 ng/ml) for 24 h with or without 1 h GTS21 pretreatment (30 μm). b Quantification of caspase activation upon GTS21 (30 μm) pretreatment for 1 h in LPS (60 ng/ml)-activated astrocyte conditioned media showed significantly lowered levels of caspase 3/7 in neuronal cultures, and this effect was significantly blocked upon addition of 1 μm MLA, *p < 0.05 compared with control astrocyte conditioned media. *p < 0.05 compared with control (one-way ANOVA with adjustment for multiple comparisons using Dunnett’s test). Error bars represent SD (n = 5 wells, 15 fields per well)

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