Fig. 7

Knockdown of AdipoR1 and p-AMPK abolished improvement in neurological function and anti-inflammatory effects of rCTRP9 at 24 h post-ICH. a Modified Garcia test, b forelimb placement test, c corner turn test, and d representative western blot images and quantitative analyses of CTRP9, AdipoR1, APPL1, p-AMPK/AMPK, p-NFκB/NFκB, TNF-α, and IL-6 at 24 h post-ICH. Values are expressed as mean ± SD. *p < 0.05, **p < 0.01 vs. sham group; #p < 0.05, ##p < 0.01 vs. ICH + vehicle group; &p < 0.05 vs. rCTRP9 + Scr siRNA, and @p < 0.05 vs. rCTRP9 + DMSO group. Scr, scramble; siRNA, small interfering RNA. N = 6