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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: K284-6111 prevents the amyloid beta-induced neuroinflammation and impairment of recognition memory through inhibition of NF-κB-mediated CHI3L1 expression

Fig. 6

K284-6111 on neuroinflammatory and amyloidogenic responses in microglial BV-2 cells and astrocytes. NO level was measured in K284-6111-treated microglial BV-2 cells (a) and astrocytes (b). CHI3L1, iNOS, COX-2, and Iba-1 proteins were detected by Western blotting using specific antibodies in K284-6111-treated microglial BV-2 cells (c). CHI3L1, iNOS, COX-2, and GFAP proteins were detected by Western blotting using specific antibodies in K284-6111-treated cultured astrocytes (d). APP and BACE1 proteins were detected by Western blotting using specific antibodies in K284-6111-treated microglial BV-2 cells (e) and cultured astrocytes (f). Each value under the band is mean ± S.D. from three experiments (c, d, e, f). #Significantly different from control group (p < 0.05). *Significantly different from LPS-treated group (p < 0.05)

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