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Table 1 Inhibitors of the NLRP3 inflammasome in ischemic stroke

From: Relevant mediators involved in and therapies targeting the inflammatory response induced by activation of the NLRP3 inflammasome in ischemic stroke

Categories

Drugs or molecules

Acting on gene expression products

MCC950, parthenolide, Bay 11-7082, MNS, omega-3 fatty acids, atorvastatin, Nrf2, ethylphenyl ketone, glibenclamide, IMM-H004, eicosapentaenoic acid, geniposide, sinomenine, corylin, minocycline, arctigenin, nicorandil, curcumin

Acting on the process of gene expression

IVIG, aloe vera, A151, chrysophanol, umbelliferone, apocynin, IFN-β, JQ1, meisoindigo, ezetimibe, edaravone, ginkgo diterpene lactones, ketone metabolite hydroxybutyrate, probenecid, nafamostat mesilate, ruscogenin, 17 β-estradiol

Acting on gene expression processes and gene expression products

miR-223, microRNA20a, miR-155-5p, miR-216a, miR-19a-3p, miR-155, miR-874-3p, procyanidins, astragaloside IV, resveratrol, sulforaphane

  1. MNS, 3,4-methylenedioxy-beta-nitrostyrene; Nrf2, nuclear factor erythrocyte 2–related factor 2; IVIG, intravenous immunoglobulin; IFN-β, interferon-β