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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: High-fat diet impairs duodenal barrier function and elicits glia-dependent changes along the gut-brain axis that are required for anxiogenic and depressive-like behaviors

Fig. 5

HFD mediates depressive- and anxiety-like behaviors by involving a glial signaling pathway. a Tail suspension and b forced swimming tests were performed at days 0 and 140 of the diet protocol to assess the depressive-like behavior. Mice were suspended by the tail on a horizontal bar or placed in a cylinder filled with heated water and immobility time (in seconds) was recorded during the last 4 min of the 6-min test. Open field test was carried out to assess anxiety-like behavior by recording the total c mobility and d immobility time (in seconds), and e the number of entries in the center of the open field during the last 10 min of the 20-min test. Data were analyzed by 2-way ANOVA and Tukey post hoc. Results are expressed as the average time in seconds or the average number of entries/min ± SEM of n assessments. ***P<0.001 and ****P<0.0001 versus SD group at day 140 (week 20), °°°P<0.001 and °°°°P<0.0001 versus HFD group at day 140 (week 20), #P<0.05 for day 0 versus day 140 within the same group

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