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Fig. 12 | Journal of Neuroinflammation

Fig. 12

From: Thymosin β4 reverses phenotypic polarization of glial cells and cognitive impairment via negative regulation of NF-κB signaling axis in APP/PS1 mice

Fig. 12

Diagram shows that Tβ4 promotes microglia phenotype shift from M1 to M2-like, and reduces production of pro-inflammatory cytokines or Aβ accumulation, improves cognitive decline, and displays antidepressant-like effect. Tβ4 intervention exerts obvious anti-inflammatory and neuroprotective effects in large part but not only by negative regulating TLR4/NF-κBp65 and NF-κBp52 signaling pathways in APP/PS1 mice

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Journal of Neuroinflammation

ISSN: 1742-2094