Fig. 6

MSR1 knockout reduced CD21-induced protection against HT in tPA-infused tMCAO mice. a Representative immunofluorescent co-staining images of IBA-1, CD86, and MSR1 around the brain injury area. b Representative immunofluorescent co-staining images of IBA-1, CD206, and MSR1 around the brain injury area. c Representative images of cerebral hemorrhage 72 h after tMCAO in wildtype (WT) and MSR1^−/− (KO) mice. d Quantification of cerebral hemorrhagic volume in each group. Scalebar (a, b) = 50 μm. The data are expressed as mean ± SD (n = 5/group). **p < 0.01, vs. tPA group in WT mice; ^$$p < 0.01, vs. tPA + CD21 group in WT mice