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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Downregulation of CD151 restricts VCAM-1 mediated leukocyte infiltration to reduce neurobiological injuries after experimental stroke

Fig. 5

The MAPK and the NF-κB pathways were inhibited after the CD151 downregulation in endothelial cells. The MAPK kinase (i.e., p38, JNK, and ERK) activation was evaluated using a–c brain tissue (n = 6 per group) and g–i in vitro (n = 3 per group) experiments. ** vs. LV Vehicle + MCAO indicates p < 0.01. The NF-κB pathway activation evaluated using the d, j IκB α degeneration and the p65 translocation from the e, k cytoplasm to the f, l nucleus in enriched endothelial cells (n = 3 per group) and in vitro (n = 3 per group). * and ** vs. LV Vehicle + MCAO indicate p < 0.05 and 0.01, respectively

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