Fig. 2

Enriched GO and KEGG of miRNAs and miRNA-mRNA interaction networks in NK cells after MCAO. Top 20 processes revealed by GO enrichment analysis to influence biological processes (a), cellular components (b), and molecular functions (c). d KEGG enrichment analysis results of all miRNA target genes. e Analysis of the regulatory networks of transcription factors for miRNA target genes. f Core miRNA-mRNA regulatory network. RHD, proteins containing the Rel homology domain (RHD) are eukaryotic transcription factors; IRF, interferon regulatory factors are proteins that regulate the transcription of interferons; PAX, paired box domain; STAT proteins, signal transducer and activator of transcription (STAT) proteins are a family of transcription factors that are specifically activated to regulate gene transcription when cells encounter cytokines and growth factors; T-box, a group of transcription factors involved in limb and heart development; ETS, in the field of molecular biology, the E26 transformation-specific (ETS) family is one of the largest families of transcription factors and is unique to animals; bHLH, a basic helix-loop-helix (bHLH) is a protein structural motif that characterizes one of the largest families of dimerizing transcription factors; Fork_head, the fork head domain is a type of protein domain that is often found in transcription factors; its purpose is to bind DNA; HMG, high-mobility group (HMG) box, HMG box domains are involved in binding DNA and may also be involved in protein-protein interactions; ZBTB, the BTB (for BR-C, ttk and bab) or POZ (for pox virus and zinc finger) domain is present near the N-terminus of a fraction of zinc finger proteins and in proteins that contain the Kelch motif, as well as a family of pox virus proteins; zf-C2H2, zinc finger, C2H2 type