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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Aging and high-fat diet feeding lead to peripheral insulin resistance and sex-dependent changes in brain of mouse model of tau pathology THY-Tau22

Fig. 7

Microgliosis marker. Iba1 DAB-stained representative right hemisphere brain sections of 11-month-old males a wt on St diet, b wt on HF diet, c THY-Tau22 on St diet, d THY-Tau22 on HF diet. Black- and white-framed inserts in left down and up right corners show magnified areas in particular color frames. Scale bar for the whole section 500 μm, for inserts 200 μm. e A representative figure of analyzed areas: hippocampus (orange), cortex (purple), and amygdala (blue). f Relative quantification at particular analyzed area (e) at right hemisphere brain sections of 7- and 11-month-old THY-Tau22 and wt mice (n = 20–25 sections per 4 mice). Wt group on St diet was set as 100 %. Data are presented as mean ± SEM and were statistically analyzed using Mann-Whitney t test within each age and sex group (*). The age comparison of brain sections (f) was performed by mixed-effects analysis and Bonferroni’s post hoc test (#). Statistical significance for all measurements: *p < 0.05; **p < 0.01; ***p < 0.001. DAB 3′,3′-diaminobenzidine, Iba1 ionized calcium-binding adapter molecule 1

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