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Table 7 Metabolic parameters of THY-Tau22 and wt mice. Eleven-month-old

From: Aging and high-fat diet feeding lead to peripheral insulin resistance and sex-dependent changes in brain of mouse model of tau pathology THY-Tau22

Parameter

Sex

wt St

wt HF

Tau22 St

Tau22 HF

Fasting glucose [mmol/l] (n = 8–14)

Male

7.74±0.69

9.06±0.63

7.11±0.58

8.74±0.26*

Cholesterol [mmol/l] (n = 7–14)

Male

0.98±0.07

3.25±0.17***, $$$

1.00±0.05

3.14±0.18***, $$$

FFA [ng/ml] (n = 8–13)

Male

0.50±0.13

0.67±0.06

0.48±0.09

0.83±0.06**

TG [mmol/l] (n = 7–14)

Male

0.35±0.03

0.53±0.04*

0.27±0.04

0.49±0.04***, $$

Leptin [ng/ml] (n = 5–14)

Male

4.71±2.06#

42.59±1.63***

0.58±0.28+

47.47±1.05***, ++

Fasting glucose [mmol/l] (n = 7–8)

Female

7.70±0.42

6.13±0.30*, $$$

7.76±0.34##

7.88±0.55+, $

Cholesterol [mmol/l] (n = 7–8)

Female

0.72±0.05

1.92±0.13***, $$$

0.76±0.09#

2.04±0.16***, $$$

FFA [ng/ml] (n = 6–8)

Female

0.41±0.04#

0.68±0.07**, $

0.34±0.04#, $

0.57±0.04**

TG [mmol/l] (n = 7–8)

Female

0.38±0.05

0.56±0.05**

0.39±0.04

0.39±0.04+

Leptin [ng/ml] (n=7–8)

Female

4.63±0.82##

38.40±1.65***, $$$

3.36±0.76 #

42.09±3.92***

  1. Fasting glucose, cholesterol, triglycerides (TG), free fatty acids (FFA), and leptin were measured in 3-, 7-, and 11-month-old males and females of both diets. The data are presented as mean ± SEM and were statistically analyzed by Mann-Whitney t test within each age and sex group (*HF vs St within the wt or Tau22 group, +Tau22 vs wt on the same diet). The age comparison was performed using mixed-effects analysis and Bonferroni’s post hoc test (#7 or 11 vs 3 months, $11 vs 7 months). Statistical significance for all measurements: *p < 0.05; **p < 0.01; ***p < 0.001