Fig. 7
GPR110-dependent improvement of visual function impaired by rCHIMERA by synaptamide and A8. A Average trace of VEP evaluated at 3 months post injury. Full-field flash VEP was elicited at a constant intensity of 3.0 cd·s/m2 with the active electrode subcutaneously inserted in the middle of the two ears. B, C Quantitative analysis of the VEP response. N1 amplitude (B) and latency (C) indicates that treatment with synaptamide or A8 increased the N1 amplitude in WT but not in GPR110 KO injured mice without affecting N1 latency. No significant difference in the N1 amplitude or latency in sham animals was observed between two genotypes. The data are expressed as mean ± SEM (n = 7–12). Each dot symbol represents each animal per group. ***p < 0.001, ****p < 0.0001 vs. Sham-WT