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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Red nucleus IL-33 facilitates the early development of mononeuropathic pain in male rats by inducing TNF-α through activating ERK, p38 MAPK, and JAK2/STAT3

Fig. 6

Red nucleus IL-33 facilitates the early development of mononeuropathic pain by activating JAK2/STAT3 signaling pathway. A Western blotting indicated that red nucleus p-JAK2 was upregulated at 1 week post-SNI, intrarubral injection of anti-IL-33 antibody inhibited the upregulation of p-JAK2 (n = 6 per group, F = 70.984, P < 0.001). B Western blotting showed that intrarubral administration of IL-33 promoted the protein expression of p-JAK2 in naive rats (n = 6 per group, F = 18.910, P < 0.001). C Immunohistochemistry showed that p-JAK2 was increased in the RN of SNI rats (F = 126.070, P < 0.001) and IL-33-induced hypersensitivity rats (F = 102.395, P < 0.001) (n = 4 per group). ***P < 0.001. Scale bars = 50 μm

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