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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Group 2 innate lymphoid cells are numerically and functionally deficient in the triple transgenic mouse model of Alzheimer’s disease

Fig. 3

Single-cell transcriptomal profiles of cultured ILC2 from 3xTg-AD mice and control wild-type mice. a scRNA-seq was performed with cultured ILC2 from 7-month-old female and male 3xTg-AD mice and age and sex-matched wild-type control mice, after 7 days of culture. Feature plots deposit the expression of the indicated genes. The red color indicates positive expression. The gray color indicates negative expression. b Percentages of Il5+ ILC2, Gzma+ ILC2, Il5+ Gzma+ ILC2 (double-positive), and Il5 Gzma ILC2 (double-negative) in cultured ILC2 from 3xTg-AD and wild-type mice, by scRNA-seq. c Genes differentially expressed between ILC2 from 3xTg-AD mice and those from control wild-type mice were identified by scRNA-seq. Gene pathway analyses were performed. d List of effector molecules and lymphocyte signaling molecules that were differentially expressed between ILC2 from 3xTg-AD mice and those from control wild-type mice. e Violin plots depicting the expression of the indicated genes. Cells were pooled from 4 female and 4 male mice per group. *p < 0.05; **p < 0.01; n.s., not significant

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