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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Group 2 innate lymphoid cells are numerically and functionally deficient in the triple transgenic mouse model of Alzheimer’s disease

Fig. 5

IL-5 treatment improved spatial recognition and learning of 7-month-old female 3xTg-AD mice. a Seven-month-old female 3xTg-AD mice were treated with IL-5 and PBS and underwent behavior tests. Experimental scheme for cytokine treatment and behavior tests. OF, open field; EPM, elevated plus maze. b Total distance traveled and the percentages of time spent in the indicated zones by open field test. c Percentages of time spent in the closed arms in the elevated plus maze test. d Percentages of time spent in the novel (N) and familiar (F) arms and percentages of entries into the novel and familiar arms in the Y-maze forced alternation test. Percentage of time: IL-5-treated t [18] = 2.42, p < 0.05. Percentage of entries: IL-5-treated t [18] = 3.7, p < 0.01. e Escape latency and escape distance to the hidden platform, the thigmotaxis rate, and swim speed during the 4 days of trials in the water maze test. Escape latency: F(1, 72) = 8.53, p < 0.01. Escape distance: F(1, 72) = 8.31, p < 0.01. Data are from 10 mice per group, 2 independent experiments. Error bars = mean ± SEM. *p < 0.05; **p < 0.01; n.s., not significant

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