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Table 3 Number of OTUs (species), Shannon H’ diversity index, and Firmicutes/Bacteroidetes of the gut microbiota in young and old rats before surgery and 7 days after surgery for control (C) and ibuprofen (IBU) treatment. At 7 days after surgery, the number of OTUs as well as Shannon’s index was significantly higher in aged compared to young rats, irrespective of treatment

From: Acute pre-operative ibuprofen improves cognition in a rat model for postoperative cognitive dysfunction

Treatment

N

Before surgery

7 days after surgery

# Species

Shannon’s

Firm/Bact

# Species

Shannon’s

Firm/Bact

Young C

7

579 ± 47

8.4 ± 0.2

0.87 ± 0.11

559 ± 46

8.2 ± 0.3

0.96 ± 0.14

Young IBU

3

529 ± 56

8.1 ± 0.3

0.81 ± 0.16

517 ± 83

8.0 ± 0.5

0.63 ± 0.13

Aged C

6

642 ± 34

8.5 ± 0.3

1.19 ± 0.14

679 ± 15

8.9 ± 0.1

0.95 ± 0.08

Aged IBU

3

632 ± 33

8.5 ± 0.1

0.91 ± 0.12

667 ± 35

8.7 ± 0.2

0.85 ± 0.07