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Fig. 10 | Journal of Neuroinflammation

Fig. 10

From: Activation of GPR40 attenuates neuroinflammation and improves neurological function via PAK4/CREB/KDM6B pathway in an experimental GMH rat model

Fig. 10

GPR40 CRISPR, PAK4 CRISPR, or KDM6B CRISPR downregulated the expression of GPR40, p-PAK4, or KDM6B after GMH. The representative bands and densitometric quantification of GPR40, p-PAK4, and KDM6B revealed the efficacy of CRISPR knockout in naive and GMH rats, n = 5 per group. Vehicle: 10% dimethyl sulfide. Data was represented as mean ± SD. *p < 0.05 vs. naive group + scr CRISPR group; &p < 0.05 vs. GMH + scr CRISPR group; one-way ANOVA, Tukey’s post hoc test; scr CRISPR, scrambled CRISPR; KO CRISPR, knockout CRISPR

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Journal of Neuroinflammation

ISSN: 1742-2094