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  1. Neuroinflammation in the rostral ventrolateral medulla (RVLM) has been associated with the pathogenesis of stress-induced hypertension (SIH). Neuronal mitochondrial dysfunction is involved in many pathological...

    Authors: Linping Wang, Tianfeng Liu, Xueping Wang, Lei Tong, Gaojun Chen, Shumin Zhou, Haili Zhang, Haisheng Liu, Wen Lu, Guohua Wang, Shuai Zhang and Dongshu Du
    Citation: Journal of Neuroinflammation 2023 20:137
  2. Multiple sclerosis (MS) is a chronic demyelinating autoimmune disorder which may cause long-term disability. MicroRNA (miRNA) are stable, non-coding molecules that have been identified in our Comprehensive Lon...

    Authors: Alicia Gonzalez-Martinez, Gauruv Bose, Hrishikesh Lokhande, Shrishti Saxena, Brian C. Healy, Mariann Polgar-Turcsanyi, Howard L. Weiner and Tanuja Chitnis
    Citation: Journal of Neuroinflammation 2023 20:136
  3. Gut microbiota plays a critical role in the regulation of immune homeostasis. Accordingly, several autoimmune disorders have been associated with dysbiosis in the gut microbiota. Notably, the dysbiosis associa...

    Authors: Carolina Prado, Alexandra Espinoza, J. Eduardo Martínez-Hernández, Joseph Petrosino, Erick Riquelme, Alberto J. M. Martin and Rodrigo Pacheco
    Citation: Journal of Neuroinflammation 2023 20:135
  4. Mutations in colony-stimulating factor 1 receptor (CSF1R) are known to cause adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP), which has been recently demonstrated as a primary m...

    Authors: Xin Li, Banglian Hu, Xiaoyan Guan, Ziwei Wang, Yuhang Zhou, Hao Sun, Xian Zhang, Yanfang Li, Xiaohua Huang, Yingjun Zhao, Xin Wang, Huaxi Xu, Yun-Wu Zhang, Zhanxiang Wang and Honghua Zheng
    Citation: Journal of Neuroinflammation 2023 20:134
  5. Traumatic brain injury (TBI) remains a major cause of death and severe disability worldwide. We found previously that treatment with exogenous naïve B cells was associated with structural and functional neurop...

    Authors: Liam J. Dwyer, Saumya Maheshwari, Emily Levy, Mark C. Poznansky, Michael J. Whalen and Ruxandra F. Sîrbulescu
    Citation: Journal of Neuroinflammation 2023 20:133
  6. Microglia are tissue resident macrophages with a wide range of critically important functions in central nervous system development and homeostasis.

    Authors: Moein Yaqubi, Adam M. R. Groh, Marie-France Dorion, Elia Afanasiev, Julia Xiao Xuan Luo, Hadi Hashemi, Sarthak Sinha, Nicholas W. Kieran, Manon Blain, Qiao-Ling Cui, Jeff Biernaskie, Myriam Srour, Roy Dudley, Jeffery A. Hall, Joshua A. Sonnen, Nathalie Arbour…
    Citation: Journal of Neuroinflammation 2023 20:132
  7. Multiple sclerosis (MS) is a disabling autoimmune demyelinating disorder affecting young people and causing significant disability. In the last decade, different microRNA (miRNA) expression patterns have been ...

    Authors: Alicia Gonzalez-Martinez, Rohit Patel, Brian C. Healy, Hrishikesh Lokhande, Anu Paul, Shrishti Saxena, Mariann Polgar-Turcsanyi, Howard L. Weiner and Tanuja Chitnis
    Citation: Journal of Neuroinflammation 2023 20:131
  8. Hepatic encephalopathy (HE) is a common complication of liver cirrhosis, associated with high morbidity and mortality, for which no brain-targeted therapies exist at present. The interplay between hyperammonem...

    Authors: Wouter Claeys, Lien Van Hoecke, Hannah Lernout, Clint De Nolf, Griet Van Imschoot, Elien Van Wonterghem, Daan Verhaege, Jonas Castelein, Anja Geerts, Christophe Van Steenkiste and Roosmarijn E. Vandenbroucke
    Citation: Journal of Neuroinflammation 2023 20:130
  9. Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by accumulation of extracellular amyloid beta (Aβ) and intracellular neurofibrillary tangles, leading to chronic activation of...

    Authors: Megan J. Lantz, Alyssa M. Roberts, Donovan D. Delgado and Robert A. Nichols
    Citation: Journal of Neuroinflammation 2023 20:129
  10. Increasing evidence has connected the development of certain neuropsychiatric disorders, as well as neurodegenerative diseases, to stress-induced dysregulation of the immune system. We have shown that escapabl...

    Authors: Austin M. Adkins, Emily M. Colby, Woong-Ki Kim, Laurie L. Wellman and Larry D. Sanford
    Citation: Journal of Neuroinflammation 2023 20:128
  11. Severe lung infection can lead to brain dysfunction and neurobehavioral disorders. The mechanisms that regulate the lung-brain axis of inflammatory response to respiratory infection are incompletely understood...

    Authors: Nuria Villalba, Yonggang Ma, Sarah A. Gahan, Aurelie Joly-Amado, Sam Spence, Xiaoyuan Yang, Kevin R. Nash and Sarah Y. Yuan
    Citation: Journal of Neuroinflammation 2023 20:127
  12. The spinocerebellar ataxias (SCAs) are devastating neurological diseases characterized by progressive cerebellar incoordination. While neurons bear the brunt of the pathology, a growing body of evidence sugges...

    Authors: Chandrakanth Reddy Edamakanti, Vishwa Mohan and Puneet Opal
    Citation: Journal of Neuroinflammation 2023 20:126
  13. The meninges, membranes surrounding the central nervous system (CNS) boundary, harbor a diverse array of immunocompetent immune cells, and therefore, serve as an immunologically active site. Meningeal immunity...

    Authors: Yun Su, Huimin Zheng, Changhe Shi, Xinwei Li, Shuyu Zhang, Guangyu Guo, Wenkai Yu, Shuo Zhang, Zhengwei Hu, Jing Yang, Zongping Xia, Chengyuan Mao and Yuming Xu
    Citation: Journal of Neuroinflammation 2023 20:125
  14. Antenatal infection/inflammation is associated with disturbances in neuronal connectivity, impaired cortical growth and poor neurodevelopmental outcomes. The pathophysiological substrate that underpins these c...

    Authors: Sharmony B. Kelly, Justin M. Dean, Valerie A. Zahra, Ingrid Dudink, Alison Thiel, Graeme R. Polglase, Suzanne L. Miller, Stuart B. Hooper, Laura Bennet, Alistair J. Gunn and Robert Galinsky
    Citation: Journal of Neuroinflammation 2023 20:124
  15. The humanized anti-α4 integrin blocking antibody natalizumab (NTZ) is an effective treatment for relapsing–remitting multiple sclerosis (RRMS) that is associated with the risk of progressive multifocal leukoen...

    Authors: Sasha Soldati, Alexander Bär, Mykhailo Vladymyrov, Dale Glavin, James L. McGrath, Fabien Gosselet, Hideaki Nishihara, Susan Goelz and Britta Engelhardt
    Citation: Journal of Neuroinflammation 2023 20:123
  16. Autoimmune neuropathies are common peripheral nervous system (PNS) disorders. Environmental influences and dietary components are known to affect the course of autoimmune diseases. Intestinal microorganisms ca...

    Authors: Yuting Meng, Xiangjie Qiu, Zhongxiang Tang, Yu Mao and Yurong Tan
    Citation: Journal of Neuroinflammation 2023 20:122
  17. Hepatic encephalopathy-induced hyperammonemia alters astrocytic glutamate metabolism in the brain, which is involved in cognitive decline. To identify specific therapeutic strategies for the treatment of hepat...

    Authors: Danbi Jo, Yeong-Hwan Lim, Yoon Seok Jung, Young-Kook Kim and Juhyun Song
    Citation: Journal of Neuroinflammation 2023 20:121
  18. Proper sight is not possible without a smooth, transparent cornea, which is highly exposed to environmental threats. The abundant corneal nerves are interspersed with epithelial cells in the anterior corneal s...

    Authors: Alexia Vereertbrugghen, Manuela Pizzano, Florencia Sabbione, Irene Angelica Keitelman, Carolina Maiumi Shiromizu, Douglas Vera Aguilar, Federico Fuentes, Cintia S. de Paiva, Mirta Giordano, Analía Trevani and Jeremías G. Galletti
    Citation: Journal of Neuroinflammation 2023 20:120
  19. Chronic inflammation significantly contributes to photoreceptor death in blinding retinal diseases such as age-related macular degeneration (AMD) and retinitis pigmentosa (RP). Bromodomain and extraterminal do...

    Authors: Xingfei Zhu, Wei Liu, Xiangcheng Tang, Yulin Chen, Xiangyu Ge, Qin Ke, Xingmiao Liang, Yuwen Gan, Yingfeng Zheng, Ming Zou, Mi Deng, Yizhi Liu, David Wan-Cheng Li and Lili Gong
    Citation: Journal of Neuroinflammation 2023 20:119
  20. Blood–spinal cord barrier (BSCB) disruption is a key event after spinal cord injury (SCI), which permits unfavorable blood-derived substances to enter the neural tissue and exacerbates secondary injury. Howeve...

    Authors: Rubing Zhou, Junzhao Li, Zhengyang Chen, Ruideng Wang, Yin Shen, Rong Zhang, Fang Zhou and Yong Zhang
    Citation: Journal of Neuroinflammation 2023 20:118
  21. New data are accumulating on gut microbial dysbiosis in Parkinson’s disease (PD), while the specific mechanism remains uncharacterized. This study aims to investigate the potential role and pathophysiological ...

    Authors: Jianjun Yu, Jianhong Meng, Zhengwei Qin, Yuan Yu, Yingxin Liang, Yanjun Wang and Dongmei Min
    Citation: Journal of Neuroinflammation 2023 20:117
  22. Discoidin Domain Receptor (DDR)-1 is activated by collagen. Nilotinib is a tyrosine kinase inhibitor that is FDA-approved for leukemia and potently inhibits DDR-1. Individuals diagnosed with mild–moderate Alzh...

    Authors: Max Stevenson, Rency Varghese, Michaeline L. Hebron, Xiaoguang Liu, Nick Ratliff, Amelia Smith, R. Scott Turner and Charbel Moussa
    Citation: Journal of Neuroinflammation 2023 20:116
  23. Microglial polarization is one of the most promising therapeutic targets for multiple central nervous system (CNS) disorders, including ischemic stroke. However, detailed transcriptional alteration of microgli...

    Authors: Yueman Zhang, Yunlu Guo, Ruqi Li, Tingting Huang, Yan Li, Wanqin Xie, Chen Chen, Weijie Chen, Jieqing Wan, Weifeng Yu and Peiying Li
    Citation: Journal of Neuroinflammation 2023 20:115
  24. Treatment of brain tumors, epilepsy, or hemodynamic abnormalities requires a craniotomy to access the brain. Nearly 1 million craniotomies are performed in the US annually, which increase to ~ 14 million world...

    Authors: Gunjan Kak, Zachary Van Roy, Cortney E. Heim, Rachel W. Fallet, Wen Shi, Axel Roers, Bin Duan and Tammy Kielian
    Citation: Journal of Neuroinflammation 2023 20:114
  25. Postoperative delirium (POD) is a frequent and debilitating complication, especially amongst high risk procedures, such as orthopedic surgery. This kind of neurocognitive disorder negatively affects cognitive ...

    Authors: Fuzhou Hua, Hong Zhu, Wen Yu, Qingcui Zheng, Lieliang Zhang, Weidong Liang, Yue Lin, Fan Xiao, Pengcheng Yi, Yanhong Xiong, Yao Dong, Hua Li, Lanran Fang, Hailin Liu, Jun Ying and Xifeng Wang
    Citation: Journal of Neuroinflammation 2023 20:113
  26. Numerous studies have found that inhibiting the expression of NLRP3 inflammasome can significantly improve depressive-like behaviors in mice, but the research on its effect on cognitive decline in depression a...

    Authors: Jia-Mei Li, Ting Hu, Xiao-Na Zhou, Ting Zhang, Jia-Hui Guo, Min-Yuan Wang, Yi-Lin Wu, Wen-Jun Su and Chun-Lei Jiang
    Citation: Journal of Neuroinflammation 2023 20:112
  27. Chronically dysregulated neuroinflammation has been implicated in neurodegenerative dementias, with separate studies reporting increased brain levels of inflammatory mediators and gliosis in Alzheimer’s diseas...

    Authors: Yuek Ling Chai, Jasinda H. Lee, Joyce R. Chong, Clive Ballard, Paul T. Francis, Brian K. Kennedy, Thiruma V. Arumugam, Christopher P. Chen, Dag Aarsland and Mitchell K. P. Lai
    Citation: Journal of Neuroinflammation 2023 20:111
  28. Depression and dysosmia have been regarded as primary neurological symptoms in COVID-19 patients, the mechanism of which remains unclear. Current studies have demonstrated that the SARS-CoV-2 envelope (E) prot...

    Authors: Wenliang Su, Jiahang Ju, Minghui Gu, Xinrui Wang, Shaozhuang Liu, Jiawen Yu and Dongliang Mu
    Citation: Journal of Neuroinflammation 2023 20:110
  29. Complex regional pain syndrome type-I (CRPS-I) causes excruciating pain that affect patients’ life quality. However, the mechanisms underlying CRPS-I are incompletely understood, which hampers the development ...

    Authors: Jie Wang, Chengyu Yin, Yushuang Pan, Yunqin Yang, Wei Li, Huadong Ni, Boyu Liu, Huimin Nie, Ruoyao Xu, Huina Wei, Yunwen Zhang, Yuanyuan Li, Qimiao Hu, Yan Tai, Xiaomei Shao, Jianqiao Fang…
    Citation: Journal of Neuroinflammation 2023 20:109
  30. Frontotemporal dementia (FTD) is a heterogeneous group of early onset and progressive neurodegenerative disorders, characterized by degeneration in the frontal and temporal lobes, which causes deterioration in...

    Authors: Irene Santos-García, Carmen Rodríguez-Cueto, Patricia Villegas, Fabiana Piscitelli, Anna Lauritano, Che-Kun J. Shen, Vincenzo Di Marzo, Javier Fernández-Ruiz and Eva de Lago
    Citation: Journal of Neuroinflammation 2023 20:108
  31. There is a need for novel fluid biomarkers tracking neuroinflammatory responses in Alzheimer’s disease (AD). Our recent cerebrospinal fluid (CSF) proteomics study revealed that migration inhibitory factor (MIF...

    Authors: Yanaika S. Hok-A-Hin, Marta del Campo, Walter A. Boiten, Erik Stoops, Melanie Vanhooren, Afina W. Lemstra, Wiesje M. van der Flier and Charlotte E. Teunissen
    Citation: Journal of Neuroinflammation 2023 20:107
  32. TNF signaling is an essential regulator of cellular homeostasis. Through its two receptors TNFR1 and TNFR2, soluble versus membrane-bound TNF enable cell death or survival in a variety of cell types. TNF-TNFRs...

    Authors: Valentina Pegoretti, Jan Bauer, Roman Fischer, Iskra Paro, Wanda Douwenga, Roland E. Kontermann, Klaus Pfizenmaier, Evelien Houben, Bieke Broux, Niels Hellings, Wia Baron, Jon D. Laman and Ulrich L. M. Eisel
    Citation: Journal of Neuroinflammation 2023 20:106
  33. Chronic cerebral ischemia induces white matter injury (WMI) contributing to cognitive decline. Both astrocytes and microglia play vital roles in the demyelination and remyelination processes, but the underlyin...

    Authors: Qian Cao, Jian Chen, Zhi Zhang, Shu Shu, Yi Qian, Lixuan Yang, Lushan Xu, Yuxin Zhang, Xinyu Bao, Shengnan Xia, Haiyan Yang, Yun Xu and Shuwei Qiu
    Citation: Journal of Neuroinflammation 2023 20:105
  34. Increasing pre-clinical evidence suggests that aerobic exercise positively modulates neuroimmune responses following traumatic nerve injury. However, meta-analyses on neuroimmune outcomes are currently still l...

    Authors: Marije L. S. Sleijser-Koehorst, Meghan A. Koop, Michel W. Coppieters, Ivo J. Lutke Schipholt, Nemanja Radisic, Carlijn R. Hooijmans and Gwendolyne G. M. Scholten-Peeters
    Citation: Journal of Neuroinflammation 2023 20:104
  35. Authors: Shufen Chen, Jens Martens-Lobenhoffer, Karin Weissenborn, Jan T. Kielstein, Ralf Lichtinghagen, Milani Deb-Chatterji, Na Li, Anita B. Tryc, Annemarie Goldbecker, Qiang Dong, Stefanie M. Bode-Böger and Hans Worthmann
    Citation: Journal of Neuroinflammation 2023 20:103

    The original article was published in Journal of Neuroinflammation 2012 9:251

  36. Postoperative pain and inflammation are significant complications following surgery. Strategies that aim to prevent excessive inflammation without hampering natural wound-healing are required for the managemen...

    Authors: Kazuha Mitsui, Sohei Hishiyama, Aakanksha Jain, Yumi Kotoda, Masako Abe, Takashi Matsukawa and Masakazu Kotoda
    Citation: Journal of Neuroinflammation 2023 20:102
  37. Patients receiving epidural or intrathecal opioids administration for neuraxial analgesia frequently suffer from an irritating itch. STING (stimulator of interferon genes), an innate immune modulator, is stron...

    Authors: Nan Li, Chunyan Wang, Yuying Zhao, Yigang Wang, Tianyu Gao, Yonghao Yu, Guolin Wang and Linlin Zhang
    Citation: Journal of Neuroinflammation 2023 20:101
  38. Tumour necrosis factor (TNF) is a pleiotropic cytokine and master regulator of the immune system. It acts through two receptors resulting in often opposing biological effects, which may explain the lack of the...

    Authors: Timon Fiedler, Richard Fairless, Kira Pichi, Roman Fischer, Fabian Richter, Roland E. Kontermann, Klaus Pfizenmaier, Ricarda Diem and Sarah K. Williams
    Citation: Journal of Neuroinflammation 2023 20:100
  39. Pyridoxal-5′-phosphate phosphatase/chronophin (PLPP/CIN) selectively dephosphorylates serine (S) 10 site on neurofibromin 2 (NF2, also known as merlin (moesin-ezrin-radixin-like protein) or schwannomin). p21-acti...

    Authors: Ji-Eun Kim, Duk-Shin Lee, Tae-Hyun Kim, Hana Park, Min-Ju Kim and Tae-Cheon Kang
    Citation: Journal of Neuroinflammation 2023 20:99
  40. Multiple sclerosis (MS) is a neuroinflammatory disease in which pregnancy leads to a temporary amelioration in disease activity as indicated by the profound decrease in relapses rate during the 3rd trimester o...

    Authors: Alberto Zenere, Sandra Hellberg, Georgia Papapavlou Lingehed, Maria Svenvik, Johan Mellergård, Charlotte Dahle, Magnus Vrethem, Johanna Raffetseder, Mohsen Khademi, Tomas Olsson, Marie Blomberg, Maria C. Jenmalm, Claudio Altafini, Mika Gustafsson and Jan Ernerudh
    Citation: Journal of Neuroinflammation 2023 20:98
  41. Ischemic stroke is characterized by the presence of reactive microglia. However, its precise involvement in stroke etiology is still unknown. We used metabolic profiling and showed that chemokine like factor 1...

    Authors: Wen-yu Ma, Qing-lin Wu, Sha-sha Wang, Hong-yun Wang, Jun-rui Ye, Hong-shuo Sun, Zhong-ping Feng, Wen-bin He, Shi-feng Chu, Zhao Zhang and Nai-hong Chen
    Citation: Journal of Neuroinflammation 2023 20:97
  42. Parkinson’s disease (PD) is mainly characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and neuroinflammation mediated by overactivated microglia a...

    Authors: Zhaolin Liu, Chenye Shen, Heng Li, Jiabin Tong, Yufei Wu, Yuanyuan Ma, Jinghui Wang, Zishan Wang, Qing Li, Xiaoshuang Zhang, Hongtian Dong, Yufang Yang, Mei Yu, Jian Wang, Renyuan Zhou, Jian Fei…
    Citation: Journal of Neuroinflammation 2023 20:96
  43. Microglia are the immune effector cells of the brain playing critical roles in immune surveillance and neuroprotection in healthy conditions, while they can sustain neuroinflammatory and neurotoxic processes i...

    Authors: Frida Lind-Holm Mogensen, Andrea Scafidi, Aurélie Poli and Alessandro Michelucci
    Citation: Journal of Neuroinflammation 2023 20:95
  44. The cholinergic anti-inflammatory pathway (CAP) has been widely studied to modulate the immune response. Current stimulating strategies are invasive or imprecise. Noninvasive low-intensity pulsed ultrasound (L...

    Authors: Tianshu Liu, Yanan Fu, Jiawei Shi, Shukun He, Dandan Chen, Wenqu Li, Yihan Chen, Li Zhang, Qing Lv, Yali Yang, Qiaofeng Jin, Jing Wang and Mingxing Xie
    Citation: Journal of Neuroinflammation 2023 20:94
  45. Peripheral inflammation is an important feature of Parkinson’s disease (PD). However, if and how CNS pathology is involved in the peripheral inflammation in PD remains to be fully investigated. Recently, the e...

    Authors: Zongran Liu, Yang Huang, Xuejing Wang, Jia-Yi Li, Can Zhang, Ying Yang and Jing Zhang
    Citation: Journal of Neuroinflammation 2023 20:93
  46. Neuroinflammation is an important component of many neurodegenerative diseases, whether as a primary cause or a secondary outcome. For that reason, either as diagnostic tools or to monitor progression and/or p...

    Authors: Marta Vicente-Rodríguez, Renzo Mancuso, Alba Peris-Yague, Camilla Simmons, Diego Gómez-Nicola, V. Hugh Perry, Federico Turkheimer, Simon Lovestone, Christine A. Parker and Diana Cash
    Citation: Journal of Neuroinflammation 2023 20:92
  47. Retinal ischemia–reperfusion (RIR) injury refers to an obstruction in the retinal blood supply followed by reperfusion. Although the molecular mechanism underlying the ischemic pathological cascade is not full...

    Authors: Yunhong Shi, Yidan Liu, Caiqing Wu, Xiuxing Liu, Wenfei Hu, Zhenlan Yang, Zhidong Li, Yangyang Li, Caibin Deng, Kun Wei, Chenyang Gu, Xuhao Chen, Wenru Su and Yehong Zhuo
    Citation: Journal of Neuroinflammation 2023 20:91
  48. Neuroinflammation has been suggested as a contributor to the pathophysiology of depression; however, large case–control studies investigating cytokine levels in the cerebrospinal fluid (CSF) from patients with...

    Authors: Nina Vindegaard Sørensen, Nis Borbye-Lorenzen, Rune Haubo Bojesen Christensen, Sonja Orlovska-Waast, Rose Jeppesen, Kristin Skogstrand and Michael Eriksen Benros
    Citation: Journal of Neuroinflammation 2023 20:90
  49. Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory demyelinating disorder of the central nervous system (CNS) triggered by autoimmune mechanisms. Microglia are activated and play a pivotal role ...

    Authors: Yun-Fan You, Man Chen, Yue Tang, Wen-Xiang Yu, Xiao-Wei Pang, Yun-Hui Chu, Hang Zhang, Ke Shang, Gang Deng, Luo-Qi Zhou, Sheng Yang, Wei Wang, Jun Xiao, Dai-Shi Tian and Chuan Qin
    Citation: Journal of Neuroinflammation 2023 20:89
  50. Despite extensive astrocyte activation in patients suffering from HIV-associated neurocognitive disorders (HAND), little is known about the contribution of astrocytes to HAND neuropathology. Here, we report th...

    Authors: Jingxian Lun, Yubin Li, Xuefeng Gao, Zelong Gong, Xiaoliang Chen, Jinhu Zou, Chengxing Zhou, Yuanyuan Huang, Bingliang Zhou, Pengwei Huang and Hong Cao
    Citation: Journal of Neuroinflammation 2023 20:87

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