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  1. Bile acids are steroid acids found predominantly in the bile of mammals. The bile acid conjugate tauroursodeoxycholic acid (TUDCA) is a neuroprotective agent in different animal models of stroke and neurologic...

    Authors: Natalia Yanguas-Casás, M Asunción Barreda-Manso, Manuel Nieto-Sampedro and Lorenzo Romero-Ramírez
    Citation: Journal of Neuroinflammation 2014 11:50
  2. Insufficient clearance by microglial cells, prevalent in several neurological conditions and diseases, is intricately intertwined with MFG-E8 expression and inflammatory responses. Electromagnetic field (EMF) ...

    Authors: Gen-Lin He, Yong Liu, Min Li, Chun-Hai Chen, Peng Gao, Zheng-Ping Yu and Xue-Sen Yang
    Citation: Journal of Neuroinflammation 2014 11:49
  3. Alzheimer’s disease (AD) is a major public health problem with substantial economic and social impacts around the world. The hallmarks of AD pathogenesis include deposition of amyloid β (Aβ), neurofibrillary t...

    Authors: Deborah Doens and Patricia L Fernández
    Citation: Journal of Neuroinflammation 2014 11:48
  4. Paroxetine, a selective serotonin reuptake inhibitor for counteracting depression, has been recently suggested as having a role in prevention of dopaminergic neuronal degeneration in substantia nigra, a hallma...

    Authors: Rong-Pei Liu, Ming Zou, Jian-Yong Wang, Juan-Juan Zhu, Jun-Mei Lai, Li-Li Zhou, Song-Fang Chen, Xiong Zhang and Jian-Hong Zhu
    Citation: Journal of Neuroinflammation 2014 11:47
  5. Susac syndrome (SuS) is a rare disorder thought to be caused by autoimmune-mediated occlusions of microvessels in the brain, retina and inner ear leading to central nervous system (CNS) dysfunction, visual dis...

    Authors: Sven Jarius, Ilka Kleffner, Jan M Dörr, Jaume Sastre-Garriga, Zsolt Illes, Eric Eggenberger, Colin Chalk, Marius Ringelstein, Orhan Aktas, Xavier Montalban, Kai Fechner, Winfried Stöcker, Erich B Ringelstein, Friedemann Paul and Brigitte Wildemann
    Citation: Journal of Neuroinflammation 2014 11:46
  6. Functional alterations in the properties of Aβ afferent fibers may account for the increased pain sensitivity observed under peripheral chronic inflammation. Among the voltage-gated sodium channels involved in...

    Authors: Mounir Belkouch, Marc-André Dansereau, Pascal Tétreault, Michael Biet, Nicolas Beaudet, Robert Dumaine, Ahmed Chraibi, Stéphane Mélik-Parsadaniantz and Philippe Sarret
    Citation: Journal of Neuroinflammation 2014 11:45
  7. Mammalian target of rapamycin (mTOR), a serine/threonine kinase, regulates many processes, including cell growth and the immune response. mTOR is also dysregulated in several neurological diseases, such as tra...

    Authors: Qin Lu, Lu Gao, Lijie Huang, Linhui Ruan, Jianjing Yang, Weilong Huang, Zhenxing Li, Yongliang Zhang, Kunlin Jin and Qichuan Zhuge
    Citation: Journal of Neuroinflammation 2014 11:44
  8. Hypoxic-ischaemic injuries such as stroke and traumatic brain injury exhibit features of a distinct neuro-inflammatory response in the hours and days post-injury. Microglial activation, elevated pro-inflammato...

    Authors: Myles Robert Minter, Moses Zhang, Robert Charles Ates, Juliet Marie Taylor and Peter John Crack
    Citation: Journal of Neuroinflammation 2014 11:43
  9. Non-cell-autonomous motor neuronal death is suggested in a mutant Cu/Zn superoxide dismutase 1 (mSOD1)-mediated amyotrophic lateral sclerosis (ALS) model, in which glial cells play significant roles in disease...

    Authors: Yiwen Cui, Katsuhisa Masaki, Ryo Yamasaki, Shihoko Imamura, Satoshi O Suzuki, Shintaro Hayashi, Shinya Sato, Yuko Nagara, Mami F Kawamura and Jun-ichi Kira
    Citation: Journal of Neuroinflammation 2014 11:42
  10. Depression has most often been diagnosed in patients with temporal lobe epilepsy (TLE), but the mechanism underlying this association remains unclear. In this study, we report that indoleamine 2,3-dioxygenase ...

    Authors: Wei Xie, Lun Cai, Yunhong Yu, Liang Gao, Limin Xiao, Qianchao He, Zhijun Ren and Yuanzheng Liu
    Citation: Journal of Neuroinflammation 2014 11:41
  11. Cervical compressive myelopathy (CCM) is caused by chronic spinal cord compression due to spondylosis, a degenerative disc disease, and ossification of the ligaments. Tip-toe walking Yoshimura (twy) mice are repo...

    Authors: Morito Takano, Soya Kawabata, Yuji Komaki, Shinsuke Shibata, Keigo Hikishima, Yoshiaki Toyama, Hideyuki Okano and Masaya Nakamura
    Citation: Journal of Neuroinflammation 2014 11:40
  12. Traumatic brain injury (TBI) enhances pro-inflammatory responses, neuronal loss and long-term behavioral deficits. Caveolins (Cavs) are regulators of neuronal and glial survival signaling. Previously we showed...

    Authors: Ingrid R Niesman, Jan M Schilling, Lee A Shapiro, Sarah E Kellerhals, Jacqueline A Bonds, Alexander M Kleschevnikov, Weihua Cui, April Voong, Stan Krajewski, Sameh S Ali, David M Roth, Hemal H Patel, Piyush M Patel and Brian P Head
    Citation: Journal of Neuroinflammation 2014 11:39
  13. Bone cancer pain (BCP) is one of the most disabling factors in patients suffering from primary bone cancer or bone metastases. Recent studies show several chemokines (for example, CCL2, CXCL10) in the spinal c...

    Authors: Jie Xu, Ming-Di Zhu, Xin Zhang, Hao Tian, Jin-Hua Zhang, Xiao-Bo Wu and Yong-Jing Gao
    Citation: Journal of Neuroinflammation 2014 11:38
  14. Lysophosphatidic acid (LPA) is a bioactive phospholipid with a potentially causative role in neurotrauma. Blocking LPA signaling with the LPA-directed monoclonal antibody B3/Lpathomab is neuroprotective in the...

    Authors: Peter J Crack, Moses Zhang, Maria Cristina Morganti-Kossmann, Andrew J Morris, Jonathan M Wojciak, Jonathan K Fleming, Ila Karve, David Wright, Maithili Sashindranath, Yona Goldshmit, Alison Conquest, Maria Daglas, Leigh A Johnston, Robert L Medcalf, Roger A Sabbadini and Alice Pébay
    Citation: Journal of Neuroinflammation 2014 11:37
  15. Sepsis- associated encephalopathy (SAE) is an early and common feature of severe infections. Oxidative stress is one of the mechanisms associated with the pathophysiology of SAE. The goal of this study was to ...

    Authors: Marina S Hernandes, Joana C D’Avila, Silvia C Trevelin, Patricia A Reis, Erika R Kinjo, Lucia R Lopes, Hugo C Castro-Faria-Neto, Fernando Q Cunha, Luiz RG Britto and Fernando A Bozza
    Citation: Journal of Neuroinflammation 2014 11:36
  16. Meningothelial cells (MECs) are the cellular components of the meninges. As such, they provide important barrier function for the central nervous system (CNS) building the interface between neuronal tissue and...

    Authors: Jia Li, Lei Fang, Peter Meyer, Hanspeter E Killer, Josef Flammer and Albert Neutzner
    Citation: Journal of Neuroinflammation 2014 11:35
  17. Parkinson’s disease is an irreversible neurodegenerative disease linked to progressive movement disorders and is accompanied by an inflammatory reaction that is believed to contribute to its pathogenesis. Sinc...

    Authors: Rocío M de Pablos, Antonio J Herrera, Ana M Espinosa-Oliva, Manuel Sarmiento, Mario F Muñoz, Alberto Machado and José L Venero
    Citation: Journal of Neuroinflammation 2014 11:34
  18. We have previously shown that, in response to microbial infection, activated Müller glia secrete inflammatory cytokines/chemokines and exhibit antimicrobial properties. The aim of this study is to understand t...

    Authors: Pawan Kumar Singh, Melissa J Shiha and Ashok Kumar
    Citation: Journal of Neuroinflammation 2014 11:33
  19. Absence of clinical and radiological activity in relapsing–remitting multiple sclerosis (RRMS) is perceived as disease remission. We explored the role of persisting inflammation during remission in disease evo...

    Authors: Silvia Rossi, Valeria Studer, Caterina Motta, Giorgio Germani, Giulia Macchiarulo, Fabio Buttari, Raffaele Mancino, Maura Castelli, Valentina De Chiara, Sagit Weiss, Gianvito Martino, Roberto Furlan and Diego Centonze
    Citation: Journal of Neuroinflammation 2014 11:32
  20. The process of neurogenesis in which new neurons are generated by proliferation and differentiation of neural stem/progenitor cells (NSCs/NPCs) has been a topic of intensive recent investigation. Investigation...

    Authors: Michael J Stuart, Frances Corrigan and Bernhard T Baune
    Citation: Journal of Neuroinflammation 2014 11:31
  21. Despite the fact that multiple sclerosis (MS) and Alzheimer’s disease (AD) share common neuroimmunological features, interferon beta 1a (IFNβ1a), the well-established treatment for the prevention of disease pr...

    Authors: Luigi Maria Edoardo Grimaldi, Giuseppe Zappalà, Francesco Iemolo, Anna Elisa Castellano, Stefano Ruggieri, Giuseppe Bruno and Andrea Paolillo
    Citation: Journal of Neuroinflammation 2014 11:30
  22. Oral atorvastatin has prevented or reversed paralysis in the multiple sclerosis (MS) model experimental autoimmune encephalomyelitis (EAE), and reduced development of new MS lesions in clinical trials. Besides...

    Authors: Martin S Weber, Thomas Prod’homme, Sawsan Youssef, Shannon E Dunn, Lawrence Steinman and Scott S Zamvil
    Citation: Journal of Neuroinflammation 2014 11:29
  23. Cyclin-dependent kinase 5 (Cdk5) is essential for brain development and function, and its deregulated expression is implicated in some of neurodegenerative diseases. We reported earlier that the forebrain-spec...

    Authors: Elias Utreras, Ryusuke Hamada, Michaela Prochazkova, Anita Terse, Satoru Takahashi, Toshio Ohshima and Ashok B Kulkarni
    Citation: Journal of Neuroinflammation 2014 11:28
  24. Interleukin 1 (IL-1) is implicated in neuroinflammation, an essential component of neurodegeneration. We evaluated the potential anti-inflammatory effect of a novel peptide antagonist of IL-1 signaling, Ilantide.

    Authors: Boris Klementiev, Shizhong Li, Irina Korshunova, Oksana Dmytriyeva, Stanislava Pankratova, Peter S Walmod, Laura K Kjær, Mattias S Dahllöf, Morten Lundh, Dan P Christensen, Thomas Mandrup-Poulsen, Elisabeth Bock and Vladimir Berezin
    Citation: Journal of Neuroinflammation 2014 11:27
  25. Chemokine (C-X3-C motif) ligand 1 (CX3CL1)/ CX3C chemokine receptor 1 (CX3CR1) signaling is important in modulating the communication between neurons and resident microglia/migrated macrophages in the central ...

    Authors: Zhiwei Tang, Yan Gan, Qiang Liu, Jun-Xiang Yin, Qingwei Liu, Jiong Shi and Fu-Dong Shi
    Citation: Journal of Neuroinflammation 2014 11:26
  26. Japanese encephalitis virus (JEV) infection leads to Japanese encephalitis (JE) in humans. JEV is transmitted through mosquitoes and maintained in a zoonotic cycle. This cycle involves pigs as the major reserv...

    Authors: Gunjan Dhawan Manocha, Ritu Mishra, Nikhil Sharma, Kanhaiya Lal Kumawat, Anirban Basu and Sunit K Singh
    Citation: Journal of Neuroinflammation 2014 11:24
  27. In neuroinflammatory diseases, macrophages can play a dual role in the process of tissue damage, depending on their activation status (M1 / M2). M1 macrophages are considered to exert damaging effects to neuro...

    Authors: Daphne YS Vogel, Priscilla DAM Heijnen, Marjolein Breur, Helga E de Vries, Anton TJ Tool, Sandra Amor and Christine D Dijkstra
    Citation: Journal of Neuroinflammation 2014 11:23
  28. Repetitive hypoxic preconditioning (RHP) creates an anti-inflammatory phenotype that protects from stroke-induced injury for months after a 2-week treatment. The mechanisms underlying long-term tolerance are u...

    Authors: Nancy L Monson, Sterling B Ortega, Sara J Ireland, Anouk JM Meeuwissen, Ding Chen, Erik J Plautz, Erin Shubel, Xiangmei Kong, Min K Li, Laura H Freriks and Ann M Stowe
    Citation: Journal of Neuroinflammation 2014 11:22
  29. The NF-κB signaling pathway orchestrates many of the intricate aspects of neuroinflammation. Astrocytic β2-adrenergic receptors have emerged as potential regulators in central nervous system inflammation and are ...

    Authors: Guy Laureys, Sarah Gerlo, Anneleen Spooren, Frauke Demol, Jacques De Keyser and Joeri L Aerts
    Citation: Journal of Neuroinflammation 2014 11:21
  30. Herpes simplex 1 (HSV-1) causes various human clinical manifestations, ranging from simple cold sores to encephalitis. Innate immune cells recognize pathogens through Toll-like receptors (TLRs), thus initiatin...

    Authors: Guilherme Pimenta Zolini, Graciela Kunrath Lima, Natália Lucinda, Mariana Almeida Silva, Marcela França Dias, Natália Lima Pessoa, Bruna Pizziolo Coura, Christiane Teixeira Cartelle, Rosa Maria Esteves Arantes, Erna Geessien Kroon and Marco Antônio Campos
    Citation: Journal of Neuroinflammation 2014 11:20
  31. We report the first case of combined retinal and CNS varicella zoster-associated vasculitis in a 49-year-old patient with multiple sclerosis who had been treated with natalizumab. He presented with a progressi...

    Authors: Xenia Kobeleva, Florian Wegner, Inez Brunotte, Mete Dadak, Reinhard Dengler and Martin Stangel
    Citation: Journal of Neuroinflammation 2014 11:19
  32. Human T-cell lymphotropic virus (HTLV-1) is the causative agent of the incapacitating, neuroinflammatory disease HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Currently, there are no dis...

    Authors: Soraya Maria Menezes, Daniele Decanine, David Brassat, Ricardo Khouri, Saul V Schnitman, Ramon Kruschewsky, Giovanni López, Carolina Alvarez, Michael Talledo, Eduardo Gotuzzo, Anne-Mieke Vandamme, Bernardo Galvão-Castro, Roland Liblau and Johan Van Weyenbergh
    Citation: Journal of Neuroinflammation 2014 11:18
  33. Nitric oxide (NO) is a signaling molecule regulating numerous cellular functions in development and disease. In the brain, neuronal injury or neuroinflammation can lead to microglial activation, which induces ...

    Authors: Zhe Qu, Fanjun Meng, Hui Zhou, Jilong Li, Quanhui Wang, Fan Wei, Jianlin Cheng, C Michael Greenlief, Dennis B Lubahn, Grace Y Sun, Siqi Liu and Zezong Gu
    Citation: Journal of Neuroinflammation 2014 11:17
  34. Although optic neuritis (ON) is a defining feature of neuromyelitis optica (NMO), appropriate animal models of NMO ON are lacking. Most NMO patients are seropositive for immunoglobulin G autoantibodies (NMO-Ig...

    Authors: Nithi Asavapanumas, Julien Ratelade, Marios C Papadopoulos, Jeffrey L Bennett, Marc H Levin and Alan S Verkman
    Citation: Journal of Neuroinflammation 2014 11:16
  35. Ischemic postconditioning has been demonstrated to be a protective procedure to brain damage caused by transient focal ischemia/reperfusion. However, it is elusive whether the protection of postconditioning ag...

    Authors: Ying Wang, Pengfei Ge, Li Yang, Chunyun Wu, Hao Zha, Tianfei Luo and Yuhong Zhu
    Citation: Journal of Neuroinflammation 2014 11:15
  36. Prophylaxis with unmethylated cytosine phosphate guanidine (CpG) oligodeoxynucleotides (ODN) protects against several systemic experimental infections. Escherichia coli is a major cause of Gram-negative neonatal ...

    Authors: Sandra Ribes, Tanja Meister, Martina Ott, Sandra Redlich, Hana Janova, Uwe-Karsten Hanisch, Stefan Nessler and Roland Nau
    Citation: Journal of Neuroinflammation 2014 11:14
  37. Although neuroinflammation has been studied extensively in animal models of cerebral ischemia, their contrasting functions are still not completely understood. A major participant in neuroinflammation is micro...

    Authors: Teresita L Briones, Julie Woods and Magdalena Wadowska
    Citation: Journal of Neuroinflammation 2014 11:13

    The Retraction Note to this article has been published in Journal of Neuroinflammation 2015 12:220

  38. Microglia can adopt different morphologies, ranging from a highly ramified to an amoeboid-like phenotype. Although morphological properties of microglia have been described in rodents, little is known about th...

    Authors: Susana G Torres-Platas, Samuel Comeau, Adeline Rachalski, Gregory Dal Bo, Cristiana Cruceanu, Gustavo Turecki, Bruno Giros and Naguib Mechawar
    Citation: Journal of Neuroinflammation 2014 11:12
  39. Although major depressive disorder imposes a serious public health burden and affects nearly one in six individuals in developed countries over their lifetimes, there is still no consensus on its pathophysiolo...

    Authors: Joshua Bloom and Yousef Al-Abed
    Citation: Journal of Neuroinflammation 2014 11:11
  40. Expression of chemokine CCL2 in the normal central nervous system (CNS) is nearly undetectable, but is significantly upregulated and drives neuroinflammation during experimental autoimmune encephalomyelitis (E...

    Authors: Debayon Paul, Shujun Ge, Yen Lemire, Evan R Jellison, David R Serwanski, Nancy H Ruddle and Joel S Pachter
    Citation: Journal of Neuroinflammation 2014 11:10
  41. Cerebral Malaria (CM) is a diffuse encephalopathy caused by Plasmodium falciparum infection. Despite availability of antimalarial drugs, CM-associated mortality remains high at approximately 30% and a subset of s...

    Authors: Wesley Solomon, Nana O Wilson, Leonard Anderson, Sidney Pitts, John Patrickson, Mingli Liu, Byron D Ford and Jonathan K Stiles
    Citation: Journal of Neuroinflammation 2014 11:9
  42. The innate immune response is the first line of defence against invading microorganisms and it is also activated in different neurologic/neurodegenerative pathological scenarios. As a result, the family of the...

    Authors: Iciar Gárate, Borja García-Bueno, José Luis Muñoz Madrigal, Javier R Caso, Luis Alou, María Luisa Gómez-Lus and Juan Carlos Leza
    Citation: Journal of Neuroinflammation 2014 11:8
  43. Several lines of evidence suggest that CCL2 could initiate the hyperalgesia of neuropathic pain by causing central sensitization of spinal dorsal horn neurons and facilitating nociceptive transmission in the s...

    Authors: Chung-Yu Huang, Ying-Ling Chen, Allen H Li, Juu-Chin Lu and Hung-Li Wang
    Citation: Journal of Neuroinflammation 2014 11:7
  44. Two families of polyunsaturated fatty acid (PUFA), omega-3 (ω-3) and omega-6 (ω-6), are required for physiological functions. The long chain ω-3 PUFAs, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA...

    Authors: Irene Paterniti, Daniela Impellizzeri, Rosanna Di Paola, Emanuela Esposito, Stacy Gladman, Ping Yip, John V Priestley, Adina T Michael-Titus and Salvatore Cuzzocrea
    Citation: Journal of Neuroinflammation 2014 11:6
  45. Chronic inflammation may contribute to neuropsychological impairments in individuals with HIV, and modulation of this inflammatory response by opiate receptor ligands is important in light of the prevalence of...

    Authors: Vadim Yuferov, Eduardo R Butelman, Ann Ho, Susan Morgello and Mary Jeanne Kreek
    Citation: Journal of Neuroinflammation 2014 11:5
  46. The translocator protein (18 kDa) (TSPO) is a mitochondrial protein expressed on reactive glial cells and a biomarker for gliosis in the brain. TSPO ligands have been shown to reduce neuroinflammation in sever...

    Authors: Marcus Karlstetter, Caroline Nothdurfter, Alexander Aslanidis, Katharina Moeller, Felicitas Horn, Rebecca Scholz, Harald Neumann, Bernhard H F Weber, Rainer Rupprecht and Thomas Langmann
    Citation: Journal of Neuroinflammation 2014 11:3
  47. Subarachnoid hemorrhage (SAH) represents a considerable health problem. To date, limited therapeutic options are available. In order to develop effective therapeutic strategies for SAH, the mechanisms involved...

    Authors: Elke Kooijman, Cora H Nijboer, Cindy TJ van Velthoven, Annemieke Kavelaars, Jozef Kesecioglu and Cobi J Heijnen
    Citation: Journal of Neuroinflammation 2014 11:2
  48. Interleukin-1 (IL-1) is a key mediator of ischaemic brain injury induced by stroke and subarachnoid haemorrhage (SAH). IL-1 receptor antagonist (IL-1Ra) limits brain injury in experimental stroke and reduces p...

    Authors: Navneet Singh, Stephen J Hopkins, Sharon Hulme, James P Galea, Margaret Hoadley, Andy Vail, Peter J Hutchinson, Samantha Grainger, Nancy J Rothwell, Andrew T King and Pippa J Tyrrell
    Citation: Journal of Neuroinflammation 2014 11:1

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