Skip to main content
Figure 3 | Journal of Neuroinflammation

Figure 3

From: Clinically relevant intronic splicing enhancer mutation in myelin proteolipid protein leads to progressive microglia and astrocyte activation in white and gray matter regions of the brain

Figure 3

PLP-ISEdel mice have a progressive astrogliosis throughout the brain. (A) Strong increase in glial fibrillary acidic protein (GFAP) staining is seen in the PLP-ISEdel mice. (B) Quantification of the GFAP staining in the outlined regions is shown as a heat map, with the average of the signal of the 2-month-old wild-type (WT) mice for each brain region used as 100%. Mean ± SEM for each brain region is indicated. (n = 5 to 6 per group). Abbreviations: hippocampus (hip); Cpu, striatum (caudate putamen).

Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094