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Figure 3 | Journal of Neuroinflammation

Figure 3

From: Immunomodulation targeting of both Aβ and tau pathological conformers ameliorates Alzheimer’s disease pathology in TgSwDI and 3xTg mouse models

Figure 3

Cognitive testing of TgSwDI and 3xTg mice using a radial arm maze. The number of errors is plotted versus the day of testing. (A) Results for TgSwDI mice. (B) Results for 3xTg mice. There are no differences between the wild-type controls and the pBri-treated TgSwDI mice. There are statistically significant differences between the vehicle control mice and the pBri-treated TgSwDI mice and wild-type controls using two-way ANOVA, and the treatment effect had P < 0.001. Newman–Keuls post hoc analyses indicate that both the wild-type controls and pBri-vaccinated Tg mice were significantly different from the control Tg mice (P < 0.001). There are no differences between the wild-type controls and the pBri-treated 3xTg mice. There are statistically significant differences between the vehicle control mice and the pBri-treated 3xTg mice and wild-type controls using two-way ANOVA, and the treatment effect had P < 0.001. Newman–Keuls post hoc analyses indicate that both the wild-type controls and pBri-vaccinated Tg mice were significantly different from the control Tg mice (P < 0.01). Tg, transgenic.

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Journal of Neuroinflammation

ISSN: 1742-2094