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Figure 3 | Journal of Neuroinflammation

Figure 3

From: Erythropoietin improves motor and cognitive deficit, axonal pathology, and neuroinflammation in a combined model of diffuse traumatic brain injury and hypoxia, in association with upregulation of the erythropoietin receptor

Figure 3

Atrophy of the corpus callosum is restored with erythropoietin (EPO) therapy in traumatic axonal injury with hypoxia (TAI + Hx) rats. Atrophy of the corpus callosum after injury was quantified on days 1, 7 and 14 after TAI and TAI + Hx with and without EPO. Photomicrographs taken 1 day postinjury depict treatment effects in the corpus callosum: Sham (A) and hypoxia (B) rats showed no change in callosal area over the course of 14 days. (C,G) There was no change in the measureable area of the corpus callosum after TAI, however there was a significant increase in the callosal area of TAI rats after EPO treatment at 1 and 7 d (D,G) when compared to sham, and at 7 d when compared to TAI. (E,H) TAI + Hx rats had a significant decrease in the area of the corpus callosum at 1 d when compared to sham. (F) With EPO treatment, area of the corpus callosum was significantly increased in TAI + Hx rats at 1 (pictured), 7 and 14 d when compared to vehicle TAI + Hx or sham controls. Data are expressed as mean ± SEM, n = 6/group. Letters matched to letters with apostrophes indicate a significant difference (P <0.05 by 2-way ANOVA with post-hoc Bonferroni test). Scale bar = 2 mm.

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Journal of Neuroinflammation

ISSN: 1742-2094