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Figure 11 | Journal of Neuroinflammation

Figure 11

From: Microglia in mouse retina contralateral to experimental glaucoma exhibit multiple signs of activation in all retinal layers

Figure 11

CD86 and Ym1 expression in the retina after 15 days of unilateral laser-induced OHT. Double immunostaining: Iba-1/CD86 (A-I) and MHC-II/Ym1 (J-L). Retinal whole-mount. In contralateral eyes (A-C) CD86 immunostaining was observed in some ameboid Iba-1+ cells in the OS (blank arrowhead) and NFL-GCL (inset). In OHT eyes (D-I) rounded Iba-1+ cells (arrow) and most ameboid Iba-1+ cells (blank arrowhead) were CD86+. Ym1 immunoreaction (J-L) was restricted to a few ameboid Iba-1+ cells (blank arrowhead) in the NFL-GCL of OHT eyes. (NFL-GCL: nerve fiber layer-ganglion cell layer; OHT: ocular hypertension; OS: photoreceptor outer segment).

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Journal of Neuroinflammation

ISSN: 1742-2094