Figure 4

B3 significantly reduces IL-6 production comparable with sham levels but not IL1-β and TNF-α following traumatic brain injury (TBI). The graphs show the levels of cytokines in the ipsilateral hemisphere of mouse brains at 4 and 24 h following TBI. (A) Il-6. (B) IL-1β (C) TNF-α. Animals received a single intravenous injection of B3 (25 mg/kg) or its isotype control (Ab isotype), 30 minutes post injury. Data are mean ± standard error of the mean of triplicates. Statistical significance of B3 treatment was detected by one way analysis of variance followed by Bonferroni post hoc analysis, *P <0.05; significance of cytokine levels as a consequence of TBI injury is indicated by ^# P <0.05.