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Figure 5 | Journal of Neuroinflammation

Figure 5

From: Intracranial administration of deglycosylated C-terminal-specific anti-Aβ antibody efficiently clears amyloid plaques without activating microglia in amyloid-depositing transgenic mice

Figure 5

CD45 expression is increased in mice receiving intracranial administration of intact but not deglycosylated anti-Aβ antibody. Panels A and B show total CD45 staining in right hippocampal regions of 20 mo. old APP transgenic mice receiving intracranial injection of deglycosylated C-terminal anti-Aβ antibody (de-2H6) (panel A) or intact anti-Aβ C-terminal antibody (2H6; panel B). Magnification = 40×, scale bar = 50 μm. Panel C shows quantification of theCD45 immunostaining as the ratio of injected (right) side to uninjected (left) side for both the hippocampal and frontal cortical injection sites * indicates P < 0.05 compared to mice injected with control IgG and de-2H6.

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Journal of Neuroinflammation

ISSN: 1742-2094