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Figure 1 | Journal of Neuroinflammation

Figure 1

From: Inhibition of NF-κB activation by 5-lipoxygenase inhibitors protects brain against injury in a rat model of focal cerebral ischemia

Figure 1

Pretreatment with BW-B 70C protects the brain from infarction and improves neurological score. (A) Photograph showing effect of BW-B 70C on TTC-stained sections, (B) Effect of BW-B 70C on infarct volume (measured in six serial coronal sections arranged from cranial to caudal regions), (C) Effect of BW-B 70C on neurological score and (D) Effect of BW-B 70C on regional cerebral blood flow (CBF). Changes in CBF were not significantly different after ischemia between the untreated (vehicle) and treatment (BW-B 70C) groups. (E) Photomicrograph of expression of 5-LOX (n = 4) at 24 h reperfusion after 20 min MCAO (magnification X200). Data for infarct volume (n = 7) and blood flow (n = 4) are presented as means ± SD. *p < 0.001 vs. vehicle. Data for neurological deficit score (n = 7) are presented as individual data points.

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Journal of Neuroinflammation

ISSN: 1742-2094