Skip to main content

Table 1 Percentage of responders and Aβ antibody isotypes

From: Boosting with intranasal dendrimeric Aβ1–15 but not Aβ1–15 peptide leads to an effective immune response following a single injection of Aβ1–40/42 in APP-tg mice

Strain

Immunogen

Prime (Y/N)

Responder^

IgG1*

IgG2a*

IgG2b*

IgM*

IgA*

WT

dAβ1–15

Y

4/4

265 ± 89

71 ± 47

257 ± 130

68 ± 22

116 ± 35

WT

dAβ1–15

N

4/4

238 ± 105

77 ± 49

742 ± 178

86 ± 21

122 ± 30

APP-tg

dAβ1–15

Y

5/7

148 ± 48

75 ± 59

214 ± 99

106 ± 15

46 ± 11

APP-tg

Aβ40/42

Y

5/6

45 ± 27

50 ± 48

234 ± 103

76 ± 21

66 ± 17

  1. ^ number of mice with detectable plasma anti-Aβ antibodies/total number mice immunized
  2. * μg/ml ± SEM; Y = yes, N = no.
Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094