Figure 3

MIP-1α Increases in Rat Brain after GD-induced SE. MIP-1α concentrations significantly increase in the hippocampus, piriform cortex and thalamus following GD-induced SE. MIP-1α concentrations peak at 24 hours after seizure onset in both the hippocampus (solid black line) and piriform cortex (solid gray line). In the thalamus (open gray line), there is a double peak at 12 and 48 hours after seizure onset. Data are given as pg/ml of tissue lysate reported as mean ± SEM. Data were analyzed using a one-way ANOVA with a post-hoc Dunnett's analysis comparing to vehicle control. (^# p < 0.05, ^## p < 0.01 hippocampus; ** p < 0.01 piriform cortex; ^$ p < 0.05, ^$$ p < 0.01 thalamus).