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Figure 1 | Journal of Neuroinflammation

Figure 1

From: Clusters of activated microglia in normal-appearing white matter show signs of innate immune activation

Figure 1

Preactive lesions are composed of clusters of HLA-DR-positive microglia. In NAWM, i.e., in the absence of apparent myelin loss (A, E: proteolipid protein) preactive lesions are defined as circumscribed nodules of activated microglia expressing HLA-DR (B, C) and CD68 (D). Preactive lesions are predominantly observed in blocks containing active lesions (E: proteolipid protein; F, G: HLA-DR). Figure 1G represents a magnification of the outlined square in (F). In some cases microglial nodules are surrounded by a halo devoid of microglia (H: HLA-DR). Original magnifications: A, B: 20×; C, D: 40×; E, F: 4×; G, H: 40×.

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Journal of Neuroinflammation

ISSN: 1742-2094