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Figure 11 | Journal of Neuroinflammation

Figure 11

From: Scutellarin regulates the Notch pathway and affects the migration and morphological transformation of activated microglia in experimentally induced cerebral ischemia in rats and in activated BV-2 microglia

Figure 11

Scutellarin increased the fluorescence intensity of F-actin, promoted the formation of projections and increased the expression of Rac1. Confocal immunofluorescence images showing the expression of F-actin (Rhodamine, red) in BV-2 microglial cells. The expression of F-actin in the control cells (A) appears to be increased in cells treated with scutellarin. Note that microglia treated with scutellarin show more projections of actin microspikes (B, C). Scale bar in A-B: 20 μm, C: 10 μm. The quantitative analysis shows that the intensity of F-actin in BV-2 microglial cells treated with scutellarin is increased compared with that of cells in control (D). Data are presented as mean ± SD (n = 3), * P <0.01. The protein expression of Rac 1 is increased in BV-2 cells treated with scutellarin, but that of RhoA remains relatively unaltered (E).

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Journal of Neuroinflammation

ISSN: 1742-2094