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Figure 5 | Journal of Neuroinflammation

Figure 5

From: Scutellarin regulates the Notch pathway and affects the migration and morphological transformation of activated microglia in experimentally induced cerebral ischemia in rats and in activated BV-2 microglia

Figure 5

Scutellarin reduced Hes-1 expression in activated microglia in vivo and in vitro . Confocal images showing the expression of transcription factor hairy and enhancer of split-1 (Hes-1) (red) in lectin + microglia (green, arrows) in the penumbral zones of middle cerebral artery occlusion (MCAO) rat (D-F) and following treatment with scutellarin (G-I). An increase in the expression of Hes-1 (E) is evident in the activated microglia (D) in MCAO rat. A noticeable reduction of Hes-1 expression (H) is observed in activated microglia (G) 7 days following treatment with scutellarin. An upregulation of Hes-1 (N) is observed in lipopolysaccharide (LPS)-activated BV-2 microglia (M) in comparison to control (J-L). Hes-1 is reduced (Q) in activated microglia treated with scutellarin. DAPI - blue. Scale bars in A-R: 50 μm.

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Journal of Neuroinflammation

ISSN: 1742-2094