Fig. 3

Treatment with Didox reverses AIS disruption. a–d AISs, immunolabeled for ankG, are reduced through 1 week post-injection. LPS-injected mice that received Didox treatment beginning at 24 h post-injection and continued for five subsequent days displayed no loss in ankG+-labeled AISs (d). Scale bar = 20 μM. e Schematic of LPS and anti-inflammatory Didox administration. f The mean ± SEM of AISs/FOV in saline-, LPS, and LPS + Didox-treated mice as a percent of saline controls. An asterisk indicates significant difference (p < 0.05) from saline, and a ¥ indicates a difference between treatment groups