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Fig. 9 | Journal of Neuroinflammation

Fig. 9

From: Isoliquiritigenin alleviates early brain injury after experimental intracerebral hemorrhage via suppressing ROS- and/or NF-κB-mediated NLRP3 inflammasome activation by promoting Nrf2 antioxidant pathway

Fig. 9

Effects of Nrf2 siRNA delivery and Nrf2 siRNA with ILG 20 mg/kg co-administration in ICH rats. Real-time RT-qPCR assay of Nrf2 after siRNA delivery 24 h following ICH (n = 6 rats/group) (a). WB assay (b) and quantification (c) of Nrf2 protein after siRNA treatment 24 h following ICH (n = 6 rats/group); mNSS score (d) at 24 h post ICH (n = 18 rats/group). BWC (f) at 24 h after ICH (n = 6 rats/group). FJC staining (g) and quantification (e) of FJC+ staining cells (n = 6 rats/group). Data represent means ± SD. Scale bar = 20 μm. **p < 0.01; *p < 0.05. *’: ICH + vehicle-2 vs. ICH + Nrf2 siRNA, p < 0.05; ICH + control scramble siRNA vs. ICH + Nrf2 siRNA, p < 0.01

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Journal of Neuroinflammation

ISSN: 1742-2094