Fig. 2

Exogenous BDNF administration upregulated TrkB expression in both the hippocampus and cortex. Real-time PCR analysis of TrkB mRNA levels in the a hippocampus and b cortex at 24 h post-infection. TrkB mRNA levels significantly increased following infection, with clearly elevated levels observed in the BDNF + PM group. Pretreatment with k252a significantly inhibited TrkB expression relative to levels observed in the BDNF + PM group. Western blot analysis assessed TrkB protein levels in the c, e hippocampus and d, f cortex showed significantly increased TrkB protein levels following infection. Administration of exogenous BDNF further increased TrkB expression, which was attenuated by treatment with k252a. **p < 0.01