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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Combined effect of non-bacteriolytic antibiotic and inhibition of matrix metalloproteinases prevents brain injury and preserves learning, memory and hearing function in experimental paediatric pneumococcal meningitis

Fig. 1

Survival, relative weight change and clinical scores of infant rats with acute pneumococcal meningitis. (a) Survival analysis revealed a significant difference of infected rats compared to mock-infected controls. Within the treatment groups, no significant differences in survival were found. Combined adjuvant therapy showed a non-significant trend (p = 0.0994) towards better survival compared to infant rats receiving CRO monotherapy. (b) Relative weight change during acute infections showed a slight increase within the first 18 hpi and a decrease of weight with the onset of clinical symptoms and treatment initiation until 42 hpi. In the combined adjuvant therapy group (Cro/Dap/Trocade), a strong trend points towards increased weight gain compared to animals receiving CRO monotherapy (Cro) at 42 hpi. (c) Clinical scores decrease upon infection until 24 hpi where the animals start to recover until 42 hpi. At 24 hpi, infant rats treated with combined adjuvant therapy displayed significantly higher clinical scores than animals treated with CRO monotherapy. Significance levels are always indicated as compared to CRO monotherapy

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Journal of Neuroinflammation

ISSN: 1742-2094