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Fig. 9 | Journal of Neuroinflammation

Fig. 9

From: URB597 protects against NLRP3 inflammasome activation by inhibiting autophagy dysfunction in a rat model of chronic cerebral hypoperfusion

Fig. 9

Effects of URB, autophagy inhibitor 3-MA, lysosome inhibitor CQ and ROS scavenger NAC on CCH-induced NLRP3 inflammasome activation and impaired mitophagy. a Representative western blot for NLRP3, cleaved CASP1, cleaved IL-1β, BNIP3, parkin, β-actin and VDAC1 in the hippocampus. b Relative optical density analysis for NLRP3 in the hippocampus. c Relative optical density analysis for cleaved CASP1 in the hippocampus. d Relative optical density analysis for cleaved IL-1β in the hippocampus. e Relative optical density analysis for BNIP3 in the hippocampus. f Relative optical density analysis for parkin in the hippocampus. Data are expressed as mean ± SEM (n = 5). *P < 0.05 versus sham group. **P < 0.05 versus BCCAo group. #P < 0.05 versus BCCAo+URB group

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Journal of Neuroinflammation

ISSN: 1742-2094