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Fig. 15 | Journal of Neuroinflammation

Fig. 15

From: Isoliquiritin ameliorates depression by suppressing NLRP3-mediated pyroptosis via miRNA-27a/SYK/NF-κB axis

Fig. 15

Effect of miRNA-27a inhibitor on isoliquiritin-generated cytoprotective effects in LPS+ATP-treated primary microglia cells. a, b mRNA levels of miRNA-27a and SYK. c Representative Western blots. d–i Protein expressions of SYK, p-NF-κB, NLRP3, cleaved Caspase-1, IL-1β, and GSDMD-N. Data are presented as mean ± SEM (n = 3 per group). ##p < 0.01, compared to blank group; *p < 0.05, **p < 0.01, compared to LPS+ATP group; &p < 0.05, &&p < 0.01, compared to LPS+ATP+Isoliquiritin group

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Journal of Neuroinflammation

ISSN: 1742-2094