Fig. 3

The effects of L-NAME on neuronal death and microglial activation following SE. L-NAME attenuates microglial activation by inhibiting p65-S276 NF-κB phosphorylation, while it does not affect CA1 neuronal death, following SE. a Representative photos for FJB-positive degenerating CA1 neurons induced by SE. b Quantification of analyses of the effect of L-NAME on SE-induced CA1 neurons. Open circles indicate each individual value. Horizontal bars indicate the mean value. Error bars indicate SEM (n = 7, respectively). c Representative photos for microglial p65-S276 NF-κB phosphorylation in the CA1 region following SE. d, e Quantification of analyses of the effect of L-NAME on microglial activation (d) and p65-S276 NF-κB phosphorylation in microglia (e). Open circles indicate each individual value. Horizontal bars indicate the mean value. Error bars indicate SEM (*^#p < 0.05 vs. control animals and vehicle, respectively; n = 7, respectively)