Fig. 8

As shown in panel a, plasma lipocalin-2 (LCN-2) levels were significantly elevated by DSS treatment, whereas panel b shows that circulating IL-6 levels significantly increased in the LPS- and paraquat-treated mice. Both IL-1β (p = 0.30; panel c) and IL-10 (p = 0.26; panel d) levels were modestly but not significantly elevated in DSS-treated mice that also received LPS + paraquat. *p < 0.05 compared to control animals, ***p < 0.001 compared to other water treatment groups