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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Small-molecule antagonist of VLA-4 (GW559090) attenuated neuro-inflammation by targeting Th17 cell trafficking across the blood-retinal barrier in experimental autoimmune uveitis

Fig. 5

Effect of GW559090 on human PBMCs migration and CD4+ T cell subsets in vitro. a The leukocyte cell number in non-adherent (N), adhered (A), and migrated (M) populations in saline-treated controls (Sal) and 10, 102, and 103 μg/ml of GW559090-treated groups. b Percentages of live cells adhered and migrated in each group. c, d CD4+ T cell subsets analyzed by Tbet and RORγt in CD4+FoxP3-live cells in adhered (c) and migrated (d) populations. Data were presented with mean ± SD, with triplicates in each condition. *P < 0.05, **P < 0.01, ***P < 0.001, using a two-tailed unpaired Student’s t test

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Journal of Neuroinflammation

ISSN: 1742-2094