Fig. 3

LPS-induced peripheral and central inflammation was reduced by 4R treatment. Levels of TNF-α and IL-1β cytokines were measured in WT and α7KO mice at 24 h. Cytokine levels in a plasma, b hippocampus, and c cortex. Two-way ANOVA followed by Tukey’s post hoc test. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, versus saline; ^#p < 0.05, ^##p < 0.01, ^###p < 0.001, ^####p < 0.0001, versus LPS/sal; ^†††p < 0.001, versus LPS/veh; ^τp < 0.05, ^ττp < 0.01, ^τττp < 0.001, comparison between mouse genotypes. Cortex IL-1β was analyzed using a nonparametric ANOVA test followed by Dunn’s post hoc test. Data are presented as mean ± SEM. n = 5 mice per group in duplicate