Microglia RAGE exacerbates the progression of neurodegeneration within the SOD1G93A murine model of amyotrophic lateral sclerosis in a sex-dependent manner

Table 1 Overrepresentation analyses dependent on AGER expression within ALS patient cervical spinal cord RNA-seq

Ingenuity canonical pathways	FDR	KEGG pathways	FDR
Hepatic fibrosis/hepatic stellate cell activation	6.46E-08	Protein digestion and absorption	3.71E-07
GP6 signaling pathway	2.69E-07	ECM-receptor interaction	2.79E-05
Agranulocyte adhesion and diapedesis	7.08E-03	Cell adhesion molecules	2.27E-02
Apelin liver signaling pathway	7.08E-03	Calcium signaling pathway	4.21E-02
Sperm motility	9.55E-03	PI3K-Akt signaling pathway	4.21E-02
Atherosclerosis Signaling	1.58E-02

Genes that were input into these analyses were significantly differentially-expressed genes with FDR < 0.05 with absolute log₂ fold change values of ≥ 0.5. Enriched pathways, FDR < 0.05

ISSN: 1742-2094