Fig. 4
IL-5 treatment did not significantly influence Aβ concentrations in 7-month-old 3xTg-AD mice. a Seven-month-old female and male 3xTg-AD mice and sex and age-matched control wild-type mice were treated with IL-5 daily for 2 days. Concentrations of IL-5 in the cerebrospinal fluid (CSF) were examined by LegendPlex assays. Data are from 4 to 6 mice per group, 2 independent experiments. t [8] = 2.61, p < 0.05. b Concentrations of soluble Aβ were examined by ELISA. Data are from 4 mice per group, 2 independent experiments. Sex effect: F [1, 12] = 36.05, p < 0.01; treatment effect: F [1, 12] = 0.029, p = 0.87; interaction: F [1, 12] = 0.026, p = 0.87. c Concentrations of insoluble Aβ were examined by ELISA. Data are from 4 mice per group, 2 independent experiments. Error bars = mean ± SEM. *p < 0.05; **p < 0.01; n.s., not significant