The potential roles of m6A modification in regulating the inflammatory response in microglia

Table 1 Detailed descriptions of the protein and mRNA in the pathways related hypo m⁶A and upregulated mRNA (M1-L vs M0-L)

Pathway	Protein	m⁶A mRNA	Protein	m⁶A mRNA	Protein	m⁶A mRNA	Protein	m⁶A mRNA
Chemokine signaling	CCL5	Ccl5	CXCL10	Cxcl10	CXCL13	Cxcl13	CXCL11	Cxcl11
	CCL22	Ccl22	Gβy	Gnb1	SOS	Sos2	Rap1	Rapla
	Gβy	Gng10	Gβy	Gng12	Gβy	Gnb5	CCL7	Ccl7
	Cdc42	Cdc42
Ubiquitin mediated proteolysis	UBE2D	Ube2d3/2d2	UBE2A	Ube2a	UBE2L3	Ube2l3	UBE2N	Ube2n
	UBE2E	Ube2e1	UBE2F	Ube2f	VHLbox	Vhl	Apc12	Cdc26
	Skp1	Skp1	UBE2W	LOC103694506
NOD-like receptor signaling	IL6	Il6	CCL5	Ccl5	CASP4	Casp4	VDAC	Vdac1/Vdac3
TNF signaling	IL6	Il6	CCL5	Ccl5	CXCL10	Cxcl10	CASP7	Casp7
B cell receptor signaling	PIR-B	Pir	SOS	Sos2	CAN	Ppp3r1
mTOR signaling	SOS	Sos2	SLC3A2	Slc3a2	V-ATPase	Atp6v1h
Toll-like receptor signaling	IL6	Il6	CCL5	Ccl5	CXCL10	Cxcl10	CXCL11	Cxcl11
Toll-like receptor signaling	IRF5	Irf5
MAPK signaling	SOS	Sos2	Raf	Araf	G12	Gng12	Ras	Rras2
	Rap1	Rap1a	PRAK	Mapkapk5	PPP3C	Ppp3r1	Cdc42	Cdc42
	MAPKAPK	Mapkapk2
HIF-1 signaling	IL6	Il6	HIF-1α	Hif1α	PGK1	Pgk1	VHL	Vhl
IL-17 signaling	IL6	Il6	CCL7	Ccl7	CXCL10	Cxcl10
T cell receptor signaling	SOS	Sos2	PPP3C	Ppp3r1	Cdc42	Cdc42
FoxO signaling	IL6 CyclinG2	Il6 Ccng2	SOS Mn-SOD	Sos2 Sod2	Raf	Araf	BNIP3	Bnip3
ErbB signaling	Raf	Araf	SOS	Sos2
Notch signaling	APH-1	LOC108348064
JAK-STAT signaling	IL6	Il6
Ras signaling	Cdc42	Cdc42	Ras	Rras2	Gβy	Gnb1	Gβy	Gnb5
Ras signaling	CaM	Calm2	Rap1	Rap1a	Gβy	Gng10	Gβy	Gng12

ISSN: 1742-2094