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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Celastrol exerts a neuroprotective effect by directly binding to HMGB1 protein in cerebral ischemia–reperfusion

Fig. 8

A Cel significantly inhibited the secretion of TNF-α induced by HMGB1 in RAW 264.7 cells. B Cel obviously decreased the secretion of TNF-α induced by the B box in RAW 264.7 cells. C Cel remarkably blocked the binding of TLR4 and RAGE receptors to the B box. ###p < 0.001 vs. control group, **p < 0.01, ***p < 0.001 vs. HMGB1 or B box group based on a one-way analysis of variance (n = 3)

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Journal of Neuroinflammation

ISSN: 1742-2094