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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Interleukin-1 blockade attenuates white matter inflammation and oligodendrocyte loss after progressive systemic lipopolysaccharide exposure in near-term fetal sheep

Fig. 7

Representative photomicrographs showing immunofluorescent staining of 4′,6-diamidino-2-phenylindole (DAPI, showing cell nuclei, blue), oligodendrocyte transcriptase factor-2 (olig-2, green) and cleaved caspase-3 (red), and the merged image in the periventricular white matter of control, LPS+vehicle and LPS+IL-1Ra groups. Scale bar = 50 μm. Arrow indicates olig-2/caspase-3+ cell. Caspase-3+ oligodendrocytes appeared more abundant in the LPS+vehicle group compared to control and LPS+IL-1Ra-treated groups. The density of caspase-3/olig-2+ oligodendrocytes in the periventricular white matter of LPS+IL-1Ra-treated fetuses was similar to controls

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Journal of Neuroinflammation

ISSN: 1742-2094