Fig. 7

AIE induction of cell death cascades in DCX-expressing neurons are reversed by galantamine. (A) AIE increased the number of cells expressing the activated form of Casp3 within DCX-labeled cells, indicating increased apoptosis in immature neurons. As with the prevention study, galantamine reversed this effect. (B) Photomicrographs include cleaved Casp3+IR (red) with DCX (green) and DAPI (blue). Closed white arrows indicate cleaved Casp3 in DCX cells. Open arrows outlined in white indicate DCX cells without cleaved Casp3. Scale bars indicate 100 μM. For each identified comparison, *p < 0.05