Fig. 5

IFN-α extensively modulates phosphorylation profiles of microglia and astrocytes in a cell-type-specific manner. A PCA of untreated and IFN-α-treated microglia and astrocytes indicate distinct phosphorylation changes with treatment times (indicated by the number adjacent to each point). B Percentage of regulated phospho-serine, -threonine and -tyrosine residues in treated microglia and astrocytes compared with untreated cells. Numbers indicate percentages. Hierarchically clustered heatmap of the top 15 significant canonical pathways at each timepoint (vs 0 min) in C microglia and D astrocytes determined by IPA. Grey: non-enriched, blue: non-significantly enriched and yellow to red bars are significantly enriched pathways