Fig. 8
From: Type I/type III IFN and related factors regulate JEV infection and BBB endothelial integrity
Schematic presentation of host innate immune factor-mediated intracellular communication for inducing IFIT expression, restricting JEV infection, and modulating hBMEC barrier integrity. During infection, hBMECs employed PRRs (TLR3, RIG-I, and MDA5) to sense JEV and subsequently triggered IRF phosphorylation and translocation to the nucleus, leading to the synthesis and secretion of IFNs, which induced IFIT expression in a JAK/STAT-dependent manner. Additionally, these upregulated immune factors differentially regulate hBMEC barrier integrity